Ghostface chasing Laurie strode
This would be kind of awkward in lore because the movie Halloween still exists in the Scream universe. Ghostface even watched Halloween and was a big fan of horror movies. So it would be really awkward and confusing for him to be chasing Larue Strode when she's not even supposed to be real for him. How can these two coexist when one character is literally a movie character inside the other's universe?